Tracking the science of quiet.
When Silence follows the research on tinnitus and hyperacusis: the treatments in development, the science behind them, and what is still unknown.
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Treatment Pipeline
Every experimental tinnitus and hyperacusis treatment we track, with its trial stage and when it might be available.
Scientific Knowledge
The main ideas about what causes tinnitus, explained plainly and linked to the researchers and evidence behind them.
Open Questions
The questions each hypothesis still has to answer, and the research that could settle them.
VideosNew!
Short videos from our YouTube channel on tinnitus research and what the data show.
Recent updates
All updatesLaunched the When Silence YouTube channel (youtube.com/@WhenSilence) with its first video, "Why Is Severe Tinnitus Ignored? What the Data Show". Every published video now has a home on the new Videos page.
Added Attune Neurosciences to the pipeline as a focused-ultrasound watchlist entry. The company names tinnitus as a target for its wearable ultrasound headband, but none of its 8 registered studies is for tinnitus. CEO Rajiv Mahadevan told us by email (14 Oct 2026) that early, unpublished results showed substantial tinnitus reduction in over half of participants. Also renamed the Hong Kong ultrasound pilot from 'TUS' to 'CUHK'.
Ebselen (SPI-1005): at the AAO-HNS 2026 Annual Meeting, Sound Pharmaceuticals presented an award-winning new analysis of its Phase 3 Meniere's data. More treated ears than placebo ears gained at least 10 dB of low-to-mid frequency hearing (pure-tone and words-in-noise, p<0.01), which the company says supports a future sudden hearing loss indication. This is a hearing result from a press release with no effect sizes, not a tinnitus result.
New paper: the AAO-HNS 2026 update of the US clinical guideline on tinnitus (Adams et al., Otolaryngology-Head and Neck Surgery). Recommends CBT and hearing aids, advises against medications, supplements and rTMS, and newly lists bimodal neuromodulation as an option.
Latest video
Why Is Severe Tinnitus Ignored? What the Data Show
More than 740 million adults live with tinnitus, and for about 120 million it is severe. Using published research and our analyses of public data, this video compares tinnitus with chronic pain to ask why a condition this common receives so little research, funding and effective treatment.